Matthew Gardson's method

Can hair follicles be regenerated? To answer this question we must start by looking back a surprising fifty years! Dermatologists at the University of Pennsylvania and in London both described a phenomenon of new hair growing in skin that had been dermabraided. This procedure sometimes referred to as “sandpapering” the face for acne scars. These dermatologists were writing about these new hair follicles in the 1950s.

There are three phases of a hair’s life. The growing period, Anagen, is also the longest. Typically a head hair will grow between two to six years before it falls out. During the Catagen phase the hair goes into the transition from growth to elimination. While this stage progresses hair development halts. Within three weeks the hair goes into its final stage, Telogen. The final outcome of this phase is the removal of the hair. This cycle continually repeats itself throughout a person’s life.

Over time the follicles may begin to shrink resulting in the malfunctioning of the hair growth process. Most often the follicles themselves do not die; instead a hair similar to the vellus hair begins to be produced.
My research is exciting because it shows we may be able to wake up these dormant follicles.

Hair Anatomy

 Hair has two separate structures - the follicle in the skin and the shaft we see.

Follicle - The follicle is a stocking-like structure that contains several layers with different jobs. At the base of the follicle is a projection formed like sticking a finger in the bottom of a stocking and pushing it in a small amount. This projection is called a papilla and it contains capillaries, or tiny blood vessels, that feed the cells. The living part of the hair is bottom part of the stocking surrounding the papilla called the bulb. This bottom part is the only part fed by the capillaries. The cells in the bulb divide every 23 to 72 hours, faster than any other cells in the body.
The follicle is surrounded by two sheaths - an inner and outer sheath. These sheaths protect and mold the growing hair shaft. The inner sheath follows the hair shaft and ends below the opening of a sebaceous (oil) gland, and sometimes an apocrine (scent) gland. The outer sheath continues all the way up to the gland. A muscle called an erector pili muscle attaches below the gland to a fibrous layer around the outer sheath. When this muscle contracts, it causes the hair to stand up.

The sebaceous gland is important because it produces sebum which is a natural conditioner. More sebum is produced after puberty. The sebum production decreases in women throughout their lives. The production also decreases in men, but not as much as in women.

Shaft - The hair shaft is made up of dead, hard protein called keratin in three layers. The inner layer is called the medulla and may not be present. The next layer is the cortex and the outer layer is the cuticle. The cortex makes up the majority of the hair shaft. The cuticle is formed by tightly packed scales in an overlapping structure similar to roof shingles. Most hair conditioning products attempt to affect the cuticle. There are pigment cells that are distributed throughout the cortex and medulla giving the hair it's characteristic color.

Hair Growth Cycle

Hair on the scalp grows about .3-.4 mm/day or about 6 inches per year. Unlike other mammals, hair growth and loss is random and not seasonal or cyclic. At any given time, a random number of hairs will be in various stages of growth and shedding.


There are three stages of hair growth: catagen, telogen, and anagen. Catagen - The catagen phase is a transitional stage and 3% of all hairs are in this phase at any time. This phase lasts for about 2-3 weeks. During this time growth stops and the outer root sheath shrinks and attaches to the root of the hair. This is the formation of what is known as a club hair.

Telogen - Telogen is the resting phase and accounts for 10-15% of all hairs. This phase lasts for about 100 days for hairs on the scalp and much longer for hairs on the eyebrow, eyelash, arm and leg.

During this phase the hair follicle is completely at rest and the club hair is completely formed. Pulling out a hair in this phase will reveal a solid, hard, dry, white material at the root. About 25-100 telogen hairs are shed normally each day.

Anagen - Anagen is the active phase of the hair. The cells in the root of the hair are dividing rapidly. A new hair is formed and pushes the club hair up the follicle and eventually out. During this phase the hair grows about 1 cm every 28 days. Scalp hair stays in this active phase of growth for 2-6 years. Some people have difficulty growing their hair beyond a certain length because they have a short active phase of growth. On the other hand, people with very long hair have a long active phase of growth. The hair on the arms, legs, eyelashes, and eyebrows have a very short active growth phase of about 30-45 days explaining why they are so much shorter than scalp hair.

Hair Shape

The amount of natural curl a hair has is determined by it's cross-sectional shape. Hair that is most similar to a circle is straight and hair that is flattened and elliptical is curly or kinky. The more circular the shaft is, the straighter it is. The more elliptical the shaft is, the curlier or kinkier the hair. The cross-sectional shape also determines the amount of shine the hair has. Straighter hair is shinier because sebum from the sebaceous gland can travel down the hair more easily. The kinkier the hair, the more difficulty the sebum has traveling down the hair, therefore the more dry or dull the hair looks.

Hair Origin

A developing fetus has all of it's hair follicles formed by week 22. At this time there are 5 million follicles on the body. One million of those are on the head, and 100,000 are on the scalp. This is the largest number of follicles we will ever have - follicles are never added during life. As the size of the body increases as we grow older, the density of the hair follicles on the skin decreases.

Structure and Function of Hair Follicles

Hair is much more complicated than it appears. It helps transmit sensory information and creates gender identity. Hair is important to the appearance of men and women. There is hair on all the major visible surfaces of the body. It is also the only body structure that is completely renewable without scarring. This article explains what exactly hair is and how it works.